Factors affecting nucleolytic efficiency of some ternary metal complexes with DNA binding and recognition domains. Crystal and molecular structure of Zn(phen)(edda)

• Main Authors: Seng, H.L., Ng, C.H., Caracelli, I., Maah, M.J., Tan, K.W., Tiekink, E.R.T., Yamin, B.M., Rahman, R.N., Ong, H.K.A.
• Format: Article
• Published: 2008
• Subjects: QD Chemistry
• Online Access: http://eprints.um.edu.my/6950/; http://ac.els-cdn.com/S0162013408001803/1-s2.0-S0162013408001803-main.pdf?_tid=8d8bc3fa-86e0-11e2-a8e6-00000aab0f02&acdnat=1362631158_ce15151c933662a1b64fe1044bcbd070

The binding selectivity of the M(phen)(edda) (M = Cu, Co, Ni, Zn; phen = 1,10-phenanthroline, edda = ethylenediaminediacetic acid) complexes towards ds(CG)(6), ds(AT)(6) and ds(CGCGAATTCGCG) B-form oligonucleotide duplexes were studied by CD spectroscopy and molecular modeling. The binding mode is i...