Peptide Mimotopes of Complex Carbohydrates in Salmonella enterica serovar typhi which React with both carbohydrate-Specific Monoclonal Antibody and Polyclonal Sera from Typhoid Patients

• Main Authors: Thong, Kwai Lin, Tang, Swee Seong, Tan, Wen Siang, Devi, Shamala
• Format: Article
• Published: Wiley 2007
• Subjects: Q Science (General); QH Natural history; QR Microbiology
• Online Access: http://eprints.um.edu.my/5601/; https://doi.org/10.1111/j.1348-0421.2007.tb03997.x

Polyclonal sera from typhoid patients and a monoclonal antibody, mAb ATVi, which recognizes the capsular polysaccharide Vi antigen (ViCPS), were used to select for peptides that mimic the ViCPS by using a phage-displayed random 12-mer peptide library. Two major common mimotopes selected from the lib...