A physiological approach to renal clearance: From premature neonates to adults

• Main Authors: Holford, Nick, O'Hanlon, Conor J., Allegaert, Karel, Anderson, Brian, Falcao, Amilcar, Simon, Nicolas, Lo, Yoke-Lin, Thomson, Alison H., Sherwin, Catherine M., Jacqz-Aigrain, Evelyne, Llanos-Paez, Carolina, Hennig, Stefanie, Mockus, Linas, Kirkpatrick, Carl
• Format: Article
• Published: Wiley 2024
• Subjects: RM Therapeutics. Pharmacology; RS Pharmacy and materia medica
• Online Access: http://eprints.um.edu.my/45774/; https://doi.org/10.1111/bcp.15978

AimsWe propose using glomerular filtration rate (GFR) as the physiological basis for distinguishing components of renal clearance.MethodsGentamicin, amikacin and vancomycin are thought to be predominantly excreted by the kidneys. A mixed-effects joint model of the pharmacokinetics of these drugs was...