Advance Heteroatom Dopants Nitrogen, Boron, Sulphur, and Phosphorus on Carbon Dots towards Histamine Detection in Fish Sample

• Main Authors: Fahmi, Mochamad Zakki, Sugito, Siti Febtria Asrini, Hanifah, Nadia Aulia, Nur'aini, Ummi Lathifah, Purwanto, Bambang, Voon, Lee Hwei
• Format: Article
• Published: Penerbit Universiti Kebangsaan Malaysia 2024
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://eprints.um.edu.my/45678/; https://doi.org/10.17576/jsm-2024-5302-09

This study introduces heteroatom-doped carbon dots (CDs), namely boron-sulphur (BS-CDs) and nitrogenphosphorus (NP-CDs), highlighting their potential as optical materials for sensitive histamine detection in sensor applications. Synthesized through facile pyrolysis of citric acid cores with non-metal dopants, resulting in confirmed graphene-like structures and uniform spheres with crystal diameters below 3 nm of BS-CDs and NP-CDs. The optical properties exhibited blue fluorescence, with emission wavelengths of 280 nm (QY 0.08%) and 420 nm (QY 1.72%) for BS-CDs and NP-CDs, respectively. Despite declined fluorescence intensities due to interfering components, both CDs demonstrated low selectivity for histamine, which increased the intensity in its presence. Notably, BS-CDs exhibited superior detectability of histamine at a low concentration of 26.3 ppm compared to 42.8 ppm for NP-CDs. Cytotoxicity studies indicated low toxicity for both CDs, positioning them as promising candidates for further development as histamine detectors