d-Amino acids differentially trigger an inflammatory environment in vitro

• Main Authors: Yap, Siew Hwei, Lee, Cheng Siang, Zulkifli, Nur Diyana, Suresh, Darshinie, Hamase, Kenji, Das, Kumitaa Theva, Rajasuriar, Reena, Leong, Kok Hoong
• Format: Article
• Published: Springer Wien 2024
• Subjects: R Medicine (General); RM Therapeutics. Pharmacology
• Online Access: http://eprints.um.edu.my/45663/; https://doi.org/10.1007/s00726-023-03360-8

Studies in vivo have demonstrated that the accumulation of D-amino acids (D-AAs) is associated with age-related diseases and increased immune activation. However, the underlying mechanism(s) of these observations are not well defined. The metabolism of D-AAs by D-amino oxidase (DAO) produces hydroge...