Anti-Inflammatory Effects of the Herbal Combination Sambiloto-Ginger-Turmeric (SIJAKUN)

Herbal medicines are currently widely used, both in developing and developed countries. Herbal medicines with combinations of ingredients have complex chemical compositions, so identification of therapeutic effects is needed to support the use of these drugs in clinical decisions. The study aims to...

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Main Authors: Handayani, Handayani, Savitri, Ardyarini Dyah, Wijaya, Afira Febriani Surya, Satriawan, Herland, Jakhmola, Vikash, Rebezov, Maksim, Zainul, Rahadian
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Published: Sami Publishing Company 2024
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Online Access:http://eprints.um.edu.my/44762/
https://doi.org/10.26655/JMCHEMSCI.2024.4.8
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spelling my.um.eprints.447622024-11-15T08:13:05Z http://eprints.um.edu.my/44762/ Anti-Inflammatory Effects of the Herbal Combination Sambiloto-Ginger-Turmeric (SIJAKUN) Handayani, Handayani Savitri, Ardyarini Dyah Wijaya, Afira Febriani Surya Satriawan, Herland Jakhmola, Vikash Rebezov, Maksim Zainul, Rahadian R Medicine (General) RM Therapeutics. Pharmacology Herbal medicines are currently widely used, both in developing and developed countries. Herbal medicines with combinations of ingredients have complex chemical compositions, so identification of therapeutic effects is needed to support the use of these drugs in clinical decisions. The study aims to identify the therapeutic effects of the herbal medicine Sambiloto-Ginger-Turmeric (SIJAKUN) using in silico. A search for secondary metabolites in Sijakun was obtained from the KnapSack database, and then treatment predictions were carried out using WAY2DRUGPASS. After that, pharmacokinetic analysis was carried out using SwissADME. Protein targets that can interact with SIJAKUN using STITCH DB and SEA targets. Hypergeometric Test with Multiple Testing Correction Benjamini-Hochberg False Discovery Rate (FDR) was used as a statistical test. The combination of herbal medicine SIJAKUN has dominant properties as an anti-inflammatory and P53 stimulant via the JUN/AP-1 pathway. SIJAKUN meets the pharmacokinetic criteria to be used as a drug. However, it is less effective for absorption in the intestine. SIJAKUN can be used as an anti-inflammatory and anti-apoptosis drug, but laboratory tests and further research are needed regarding drug preparations to increase absorption in the intestine. © 2024 by SPC (Sami Publishing Company). Sami Publishing Company 2024 Article PeerReviewed Handayani, Handayani and Savitri, Ardyarini Dyah and Wijaya, Afira Febriani Surya and Satriawan, Herland and Jakhmola, Vikash and Rebezov, Maksim and Zainul, Rahadian (2024) Anti-Inflammatory Effects of the Herbal Combination Sambiloto-Ginger-Turmeric (SIJAKUN). Journal of Medicinal and Chemical Sciences, 7 (4). pp. 637-648. ISSN 2651-4702, DOI https://doi.org/10.26655/JMCHEMSCI.2024.4.8 <https://doi.org/10.26655/JMCHEMSCI.2024.4.8>. https://doi.org/10.26655/JMCHEMSCI.2024.4.8 10.26655/JMCHEMSCI.2024.4.8
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine (General)
RM Therapeutics. Pharmacology
spellingShingle R Medicine (General)
RM Therapeutics. Pharmacology
Handayani, Handayani
Savitri, Ardyarini Dyah
Wijaya, Afira Febriani Surya
Satriawan, Herland
Jakhmola, Vikash
Rebezov, Maksim
Zainul, Rahadian
Anti-Inflammatory Effects of the Herbal Combination Sambiloto-Ginger-Turmeric (SIJAKUN)
description Herbal medicines are currently widely used, both in developing and developed countries. Herbal medicines with combinations of ingredients have complex chemical compositions, so identification of therapeutic effects is needed to support the use of these drugs in clinical decisions. The study aims to identify the therapeutic effects of the herbal medicine Sambiloto-Ginger-Turmeric (SIJAKUN) using in silico. A search for secondary metabolites in Sijakun was obtained from the KnapSack database, and then treatment predictions were carried out using WAY2DRUGPASS. After that, pharmacokinetic analysis was carried out using SwissADME. Protein targets that can interact with SIJAKUN using STITCH DB and SEA targets. Hypergeometric Test with Multiple Testing Correction Benjamini-Hochberg False Discovery Rate (FDR) was used as a statistical test. The combination of herbal medicine SIJAKUN has dominant properties as an anti-inflammatory and P53 stimulant via the JUN/AP-1 pathway. SIJAKUN meets the pharmacokinetic criteria to be used as a drug. However, it is less effective for absorption in the intestine. SIJAKUN can be used as an anti-inflammatory and anti-apoptosis drug, but laboratory tests and further research are needed regarding drug preparations to increase absorption in the intestine. © 2024 by SPC (Sami Publishing Company).
format Article
author Handayani, Handayani
Savitri, Ardyarini Dyah
Wijaya, Afira Febriani Surya
Satriawan, Herland
Jakhmola, Vikash
Rebezov, Maksim
Zainul, Rahadian
author_facet Handayani, Handayani
Savitri, Ardyarini Dyah
Wijaya, Afira Febriani Surya
Satriawan, Herland
Jakhmola, Vikash
Rebezov, Maksim
Zainul, Rahadian
author_sort Handayani, Handayani
title Anti-Inflammatory Effects of the Herbal Combination Sambiloto-Ginger-Turmeric (SIJAKUN)
title_short Anti-Inflammatory Effects of the Herbal Combination Sambiloto-Ginger-Turmeric (SIJAKUN)
title_full Anti-Inflammatory Effects of the Herbal Combination Sambiloto-Ginger-Turmeric (SIJAKUN)
title_fullStr Anti-Inflammatory Effects of the Herbal Combination Sambiloto-Ginger-Turmeric (SIJAKUN)
title_full_unstemmed Anti-Inflammatory Effects of the Herbal Combination Sambiloto-Ginger-Turmeric (SIJAKUN)
title_sort anti-inflammatory effects of the herbal combination sambiloto-ginger-turmeric (sijakun)
publisher Sami Publishing Company
publishDate 2024
url http://eprints.um.edu.my/44762/
https://doi.org/10.26655/JMCHEMSCI.2024.4.8
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score 13.214268