Bisacodyl overcomes morphine-induced constipation by decreasing colonic Aquaporin-3 and Aquaporin-4 expression

• Main Authors: Rahmadi, Mahardian, Ardianto, Chrismawan, Nurhan, Ahmad D., Chasanah, Rafiqa A., Krismonika, Dewi I., Puspitasari, Arina D., Suprapti, Budi, Segaran, Santhra, Phan, Chia Wei, Khotib, Junaidi
• Format: Article
• Published: Belgorod State National Research University 2022
• Subjects: RS Pharmacy and materia medica
• Online Access: http://eprints.um.edu.my/44063/

Introduction: Morphine is an opioid prescribed to treat aches and pains. However, morphine often causes opioid-induced constipation (OIC). Aquaporin (AQP) transporters, especially AQP3 and AQP4, play an essential role in mediating constipation. Bisacodyl is a common laxative used to treat constipati...