Optimization of a cefuroxime axetil-loaded liquid self-nanoemulsifying drug delivery system: enhanced solubility, dissolution and caco-2 cell uptake
Cefuroxime axetil (CA) is an oral cephalosporin which hydrolyzes rapidly to the active parent compound cefuroxime. CA is known to have incomplete oral bioavailability (30-50%) due to its poor solubility and enzymatic conversion to cefuroxime in the gut lumen. In order to overcome these drawbacks, a...
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Main Authors: | , , , , , , |
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Format: | Article |
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MDPI
2022
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Online Access: | http://eprints.um.edu.my/42927/ |
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