Optimization of a cefuroxime axetil-loaded liquid self-nanoemulsifying drug delivery system: enhanced solubility, dissolution and caco-2 cell uptake

• Main Authors: Khan, Arshad Ali, Atiya, Akhtar, Akhtar, Safia, Yadav, Yogesh, Qureshi, Kamal A., Jaremko, Mariusz, Mahmood, Syed
• Format: Article
• Published: MDPI 2022
• Subjects: RM Therapeutics. Pharmacology; RS Pharmacy and materia medica
• Online Access: http://eprints.um.edu.my/42927/

Cefuroxime axetil (CA) is an oral cephalosporin which hydrolyzes rapidly to the active parent compound cefuroxime. CA is known to have incomplete oral bioavailability (30-50%) due to its poor solubility and enzymatic conversion to cefuroxime in the gut lumen. In order to overcome these drawbacks, a...