Apoferritin-encapsulated jerantinine A for transferrin receptor targeting and enhanced selectivity in breast cancer therapy

• Main Authors: Abuzaid, Haneen, Abdelrazig, Salah, Ferreira, Lenny, Collins, Hilary M., Kim, Dong-Hyun, Lim, Kuan-Hon, Kam, Toh-Seok, Turyanska, Lyudmila, Bradshaw, Tracey D.
• Format: Article
• Published: American Chemical Society 2022
• Subjects: RC Internal medicine
• Online Access: http://eprints.um.edu.my/41924/

The O-acetyl (or acetate) derivative of the Aspidosperma alkaloid Jerantinine A (JAa) elicits anti-tumor activity against cancer cell lines including mammary carcinoma cell lines irrespective of receptor status (0.14 < GI50 < 0.38 mu M), targeting microtubule dynamics. By exploiting breast can...