Optimal control of cancer chemotherapy with delays and state constraints

• Main Authors: Tan, Poh Ling, Maurer, Helmut, Kanesan, Jeevan, Chuah, Joon Huang
• Format: Article
• Published: Springer/Plenum Publishers 2022
• Subjects: RC0254 Neoplasms. Tumors. Oncology (including Cancer); T Technology (General)
• Online Access: http://eprints.um.edu.my/41702/

A mathematical model of cancer chemotherapy is considered as an optimal control problem with the objective of either minimizing a weighted sum of tumor cells and drug dosage or the terminal tumor volume. The control process is subject to three state constraints involving an upper bound on drug toxic...