Total body irradiation or chemotherapy conditioning in childhood ALL: A multinational, randomized, noninferiority phase III study

• Main Authors: Peters, Christina, Dalle, Jean-Hugues, Locatelli, Franco, Poetschger, Ulrike, Sedlacek, Petr, Buechner, Jochen, Shaw, Peter J., Staciuk, Raquel, Ifversen, Marianne, Pichler, Herbert, Vettenranta, Kim, Svec, Peter, Aleinikova, Olga, Stein, Jerry, Gungor, Tayfun, Toporski, Jacek, Truong, Tony H., Diaz-de-Heredia, Cristina, Bierings, Marc, Mohd Ariffin, Hany, Essa, Mohammed, Burkhardt, Birgit, Schultz, Kirk, Meisel, Roland, Lankester, Arjan, Ansari, Marc, Schrappe, Martin, von Stackelberg, Arend, Balduzzi, Adriana, Corbacioglu, Selim, Bader, Peter, Grp, IBFM Study, Grp, IntReALL Study, Grp, I-BFM SCT Study, Party, EBMT Paediat Dis Working
• Format: Article
• Published: American Society of Clinical Oncology 2021
• Subjects: RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://eprints.um.edu.my/34704/

PURPOSE Total body irradiation (TBI) before allogeneic hematopoietic stem cell transplantation (HSCT) in pediatric patients with acute lymphoblastic leukemia (ALL) is efficacious, but long-term side effects are concerning. We investigated whether preparative combination chemotherapy could replace TB...