Novel Gemcitabine-Re(I) bisquinolinyl complex combinations and formulations with liquid crystalline nanoparticles for pancreatic cancer photodynamic therapy

• Main Authors: Liew, Hui Shan, Mai, Chun-Wai, Zulkefeli, Mohd, Madheswaran, Thiagarajan, Kiew, Lik Voon, Pua, Lesley Jia Wei, Hii, Ling Wei, Lim, Wei Meng, Low, May Lee
• Format: Article
• Published: Frontiers Media 2022
• Subjects: RC0254 Neoplasms. Tumors. Oncology (including Cancer); RM Therapeutics. Pharmacology
• Online Access: http://eprints.um.edu.my/41630/

With less than 10% of 5-year survival rate, pancreatic ductal adenocarcinoma (PDAC) is known to be one of the most lethal types of cancer. Current literature supports that gemcitabine is the first-line treatment of PDAC. However, poor cellular penetration of gemcitabine along with the acquired and i...