Improved plasma stability and sustained release profile of gemcitabine via polypeptide conjugation

• Main Authors: Kiew, Lik Voon, Cheong, Soon Keng, Sidik, Khalifah, Chung, Lip Yong
• Format: Article
• Language: English
• Published: Elsevier 2010
• Subjects: R Medicine (General); RM Therapeutics. Pharmacology; RS Pharmacy and materia medica
• Online Access: http://eprints.um.edu.my/2642/1/Kiew_LV_2010.pdf; http://eprints.um.edu.my/2642/; https://doi.org/10.1016/j.ijpharm.2010.03.010

To enhance the stability of the anticancer drug gemcitabine (2′-deoxy-2′,2′-difluorocytidine), it was conjugated to poly-l-glutamic acid (PG-H) via a carbodiimide reaction. The synthesised poly-l-glutamic acid-gemcitabine (PG-G) was purified and characterised by using SDS-PAGE to estimate its molecu...