Platanosides, a potential botanical drug combination, decrease liver injury caused by acetaminophen overdose in mice
ABSTRACT: Oxidative stress plays an important role in acetaminophen (APAP)-induced hepatotoxicity. Platanosides (PTSs) isolated from the American sycamore tree (Platanus occidentalis) represent a potential new four-molecule botanical drug class of antibiotics active against drug-resistant infectious...
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my.um.eprints.416212023-11-08T02:26:29Z http://eprints.um.edu.my/41621/ Platanosides, a potential botanical drug combination, decrease liver injury caused by acetaminophen overdose in mice Samuvel, Devadoss J. Nguyen, Nga T. Jaeschke, Hartmut Lemasters, John J. Wang, Xiaojuan Choo, Yeun Mun Hamann, Mark T. Zhong, Zhi QD Chemistry RM Therapeutics. Pharmacology ABSTRACT: Oxidative stress plays an important role in acetaminophen (APAP)-induced hepatotoxicity. Platanosides (PTSs) isolated from the American sycamore tree (Platanus occidentalis) represent a potential new four-molecule botanical drug class of antibiotics active against drug-resistant infectious disease. Preliminary studies have suggested that PTSs are safe and well tolerated and have antioxidant properties. The potential utility of PTSs in decreasing APAP hepatotoxicity in mice in addition to an assessment of their potential with APAP for the control of infectious diseases along with pain and pyrexia associated with a bacterial infection was investigated. On PTS treatment in mice, serum alanine aminotransferase (ALT) release, hepatic centrilobular necrosis, and 4-hydroxynonenal (4-HNE) were markedly decreased. In addition, inducible nitric oxide synthase (iNOS) expression and c-JunN-terminal kinase (JNK) activation decreased when mice overdosed with APAP were treated with PTSs. Computational studies suggested that PTSs may act as JNK-1/2 and Keap1-Nrf2 inhibitors and that the isomeric mixture could provide greater efficacy than the individual molecules. Overall, PTSs represent promising botanical drugs for hepatoprotection and drug-resistant bacterial infections and are effective in protecting against APAP-related hepatotoxicity, which decreases liver necrosis and inflammation, iNOS expression, and oxidative and nitrative stresses, possibly by preventing persistent JNK activation. American Chemical Society 2022-07-22 Article PeerReviewed Samuvel, Devadoss J. and Nguyen, Nga T. and Jaeschke, Hartmut and Lemasters, John J. and Wang, Xiaojuan and Choo, Yeun Mun and Hamann, Mark T. and Zhong, Zhi (2022) Platanosides, a potential botanical drug combination, decrease liver injury caused by acetaminophen overdose in mice. Journal of Natural Products, 85 (7). pp. 1779-1788. ISSN 0163-3864, DOI https://doi.org/10.1021/acs.jnatprod.2c00324 <https://doi.org/10.1021/acs.jnatprod.2c00324>. 10.1021/acs.jnatprod.2c00324 |
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QD Chemistry RM Therapeutics. Pharmacology Samuvel, Devadoss J. Nguyen, Nga T. Jaeschke, Hartmut Lemasters, John J. Wang, Xiaojuan Choo, Yeun Mun Hamann, Mark T. Zhong, Zhi Platanosides, a potential botanical drug combination, decrease liver injury caused by acetaminophen overdose in mice |
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ABSTRACT: Oxidative stress plays an important role in acetaminophen (APAP)-induced hepatotoxicity. Platanosides (PTSs) isolated from the American sycamore tree (Platanus occidentalis) represent a potential new four-molecule botanical drug class of antibiotics active against drug-resistant infectious disease. Preliminary studies have suggested that PTSs are safe and well tolerated and have antioxidant properties. The potential utility of PTSs in decreasing APAP hepatotoxicity in mice in addition to an assessment of their potential with APAP for the control of infectious diseases along with pain and pyrexia associated with a bacterial infection was investigated. On PTS treatment in mice, serum alanine aminotransferase (ALT) release, hepatic centrilobular necrosis, and 4-hydroxynonenal (4-HNE) were markedly decreased. In addition, inducible nitric oxide synthase (iNOS) expression and c-JunN-terminal kinase (JNK) activation decreased when mice overdosed with APAP were treated with PTSs. Computational studies suggested that PTSs may act as JNK-1/2 and Keap1-Nrf2 inhibitors and that the isomeric mixture could provide greater efficacy than the individual molecules. Overall, PTSs represent promising botanical drugs for hepatoprotection and drug-resistant bacterial infections and are effective in protecting against APAP-related hepatotoxicity, which decreases liver necrosis and inflammation, iNOS expression, and oxidative and nitrative stresses, possibly by preventing persistent JNK activation. |
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Article |
author |
Samuvel, Devadoss J. Nguyen, Nga T. Jaeschke, Hartmut Lemasters, John J. Wang, Xiaojuan Choo, Yeun Mun Hamann, Mark T. Zhong, Zhi |
author_facet |
Samuvel, Devadoss J. Nguyen, Nga T. Jaeschke, Hartmut Lemasters, John J. Wang, Xiaojuan Choo, Yeun Mun Hamann, Mark T. Zhong, Zhi |
author_sort |
Samuvel, Devadoss J. |
title |
Platanosides, a potential botanical drug combination, decrease liver injury caused by acetaminophen overdose in mice |
title_short |
Platanosides, a potential botanical drug combination, decrease liver injury caused by acetaminophen overdose in mice |
title_full |
Platanosides, a potential botanical drug combination, decrease liver injury caused by acetaminophen overdose in mice |
title_fullStr |
Platanosides, a potential botanical drug combination, decrease liver injury caused by acetaminophen overdose in mice |
title_full_unstemmed |
Platanosides, a potential botanical drug combination, decrease liver injury caused by acetaminophen overdose in mice |
title_sort |
platanosides, a potential botanical drug combination, decrease liver injury caused by acetaminophen overdose in mice |
publisher |
American Chemical Society |
publishDate |
2022 |
url |
http://eprints.um.edu.my/41621/ |
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1783876729428770816 |
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13.160551 |