Acetaminophen-induced microvascular injury in the rat liver: protection with misoprostol

• Main Authors: Lim, S.P., Andrews, F.J., O'Brien, P.E.
• Format: Article
• Published: Faculty of Medicine, University of Malaya 1996
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/24482/; https://jummec.um.edu.my/issue/view/661/Vol.1%2C%20No.2%2C%201996

Studies into the mechanism of acetaminophen (APAP)-induced hepatotoxicity have focused mainly at the hepatocellular level. This study aimed to investigate the effect of acetaminophen on the hepatic microvasculature using a vascular casting technique. Acetaminophen was administered at a dose of 650 m...