Antitubercular activity assessment of fluorinated chalcones, 2-aminopyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives: In vitro, molecular docking and in-silico drug likeliness studies

• Main Authors: Lagu, Surendra Babu, Yejella, Rajendra Prasad, Nissankararao, Srinath, Bhandare, Richie R., Golla, Venu Sampath, Lokesh, Bontha Venkata Subrahmanya, Rahman, M. Mukhlesur, Shaik, Afzal Basha
• Format: Article
• Published: Public Library of Science 2022
• Subjects: RM Therapeutics. Pharmacology
• Online Access: http://eprints.um.edu.my/41493/

A series of newer previously synthesized fluorinated chalcones and their 2-amino-pyridine3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives were screened for their in vitro antitubercular activity and in silico methods. Compound 40 (MIC similar to 8 mu M) was the most potent among all 60...