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Production and first use of (SmCl3)-Sm-153-ion exchange resin capsule formulation for assessing gastrointestinal motility

We produced an enteric-coated gelatine capsule containing neutron-activated Sm-153-labelled resin beads for use in gastrointestinal motility studies. In vitro test in simulated gastrointestinal environment and in vivo study on volunteers were performed. Scintigraphic images were acquired from ten vo...

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Main Authors: Yeong, C.H., Abdullah, B.J.J., Ng, K.H., Chung, L.Y., Goh, K.L., Sarji, S.A., Perkins, A.C.
Format: Article
Language:English
English
Published: 2012
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/4147/1/Production_and_first_use_of_%28SmCl3%29-Sm-153-ion_exchange_resin_capsule_formulation_for_assessing_gastrointestinal_motility.pdf
http://eprints.um.edu.my/4147/2/smcl3.pdf
http://eprints.um.edu.my/4147/
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spelling my.um.eprints.41472013-01-07T02:48:52Z http://eprints.um.edu.my/4147/ Production and first use of (SmCl3)-Sm-153-ion exchange resin capsule formulation for assessing gastrointestinal motility Yeong, C.H. Abdullah, B.J.J. Ng, K.H. Chung, L.Y. Goh, K.L. Sarji, S.A. Perkins, A.C. R Medicine We produced an enteric-coated gelatine capsule containing neutron-activated Sm-153-labelled resin beads for use in gastrointestinal motility studies. In vitro test in simulated gastrointestinal environment and in vivo study on volunteers were performed. Scintigraphic images were acquired from ten volunteers over 24 h while blood and urine samples were collected to monitor the presence of Sm-153. All the capsules remained intact in stomach. This proved to be a safe and practical oral capsule formulation for whole gut transit scintigraphy. (C) 2011 Elsevier Ltd. All rights reserved. 2012 Article PeerReviewed application/pdf en http://eprints.um.edu.my/4147/1/Production_and_first_use_of_%28SmCl3%29-Sm-153-ion_exchange_resin_capsule_formulation_for_assessing_gastrointestinal_motility.pdf application/pdf en http://eprints.um.edu.my/4147/2/smcl3.pdf Yeong, C.H. and Abdullah, B.J.J. and Ng, K.H. and Chung, L.Y. and Goh, K.L. and Sarji, S.A. and Perkins, A.C. (2012) Production and first use of (SmCl3)-Sm-153-ion exchange resin capsule formulation for assessing gastrointestinal motility. Applied Radiation and Isotopes, 70 (3). pp. 450-455. ISSN 0969-8043 10.1016/j.apradiso.2011.11.056
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
English
topic R Medicine
spellingShingle R Medicine
Yeong, C.H.
Abdullah, B.J.J.
Ng, K.H.
Chung, L.Y.
Goh, K.L.
Sarji, S.A.
Perkins, A.C.
Production and first use of (SmCl3)-Sm-153-ion exchange resin capsule formulation for assessing gastrointestinal motility
description We produced an enteric-coated gelatine capsule containing neutron-activated Sm-153-labelled resin beads for use in gastrointestinal motility studies. In vitro test in simulated gastrointestinal environment and in vivo study on volunteers were performed. Scintigraphic images were acquired from ten volunteers over 24 h while blood and urine samples were collected to monitor the presence of Sm-153. All the capsules remained intact in stomach. This proved to be a safe and practical oral capsule formulation for whole gut transit scintigraphy. (C) 2011 Elsevier Ltd. All rights reserved.
format Article
author Yeong, C.H.
Abdullah, B.J.J.
Ng, K.H.
Chung, L.Y.
Goh, K.L.
Sarji, S.A.
Perkins, A.C.
author_facet Yeong, C.H.
Abdullah, B.J.J.
Ng, K.H.
Chung, L.Y.
Goh, K.L.
Sarji, S.A.
Perkins, A.C.
author_sort Yeong, C.H.
title Production and first use of (SmCl3)-Sm-153-ion exchange resin capsule formulation for assessing gastrointestinal motility
title_short Production and first use of (SmCl3)-Sm-153-ion exchange resin capsule formulation for assessing gastrointestinal motility
title_full Production and first use of (SmCl3)-Sm-153-ion exchange resin capsule formulation for assessing gastrointestinal motility
title_fullStr Production and first use of (SmCl3)-Sm-153-ion exchange resin capsule formulation for assessing gastrointestinal motility
title_full_unstemmed Production and first use of (SmCl3)-Sm-153-ion exchange resin capsule formulation for assessing gastrointestinal motility
title_sort production and first use of (smcl3)-sm-153-ion exchange resin capsule formulation for assessing gastrointestinal motility
publishDate 2012
url http://eprints.um.edu.my/4147/1/Production_and_first_use_of_%28SmCl3%29-Sm-153-ion_exchange_resin_capsule_formulation_for_assessing_gastrointestinal_motility.pdf
http://eprints.um.edu.my/4147/2/smcl3.pdf
http://eprints.um.edu.my/4147/
_version_ 1643687272805040128
score 13.15806

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