Reproducibility of neutron activated Sm-153 oral dose formulations intended for human administration

• Main Authors: Yeong, C.H., Blackshaw, P.E., Ng, K.H., Abdullah, B.J.J., Blaauw, M., Dansereau, R.J., Perkins, A.C.
• Format: Article
• Language: English; English
• Published: 2011
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/4148/1/sm-153.pdf; http://eprints.um.edu.my/4148/2/Production_and_first_use_of_%28SmCl3%29-Sm-153-ion_exchange_resin_capsule_formulation_for_assessing_gastrointestinal_motility.pdf; http://eprints.um.edu.my/4148/

Neutron activation of Sm-152 offers a method of radiolabeling for the in vivo study of oral dose formulations by gamma scintigraphy. Reproducibility measurements are needed to ensure the robustness of clinical studies. 204 enteric-coated guaifenesin core tablets (10 mg of Sm(2)O(3)) were irradiated...