Regulatory network of BLIMP1, IRF4, and XBP1 triad in plasmacytic differentiation and multiple myeloma pathogenesis

• Main Authors: Tang, Ting Fang, Chan, Yee Teng, Cheong, Heng Choon, Cheok, Yi Ying, Anuar, Nur Adila, Looi, Chung Yeng, Gan, Gin Gin, Wong, Won Fen
• Format: Article
• Published: Academic Press Inc Elsevier Science 2022
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/41302/

Antibody secreting plasma cell plays an indispensable role in humoral immunity. As activated B cell undergoes germinal center reaction and develops into plasma cell, it gradually loses B cell characteristics and embraces functional changes associated with immunoglobulins production. Differentiation...