Zerumbone-loaded nanostructured lipid carrier gel enhances wound healing in diabetic rats
This study investigated the healing effects of topical application of zerumbone, a well-known anti-inflammatory compounds loaded on nanostructured lipid carrier gel (Carbopol 940) (ZER-NLCG) on excisional wounds in streptozotocin-induced diabetic rats. Diabetic rats with inflicted superficial skin w...
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my.um.eprints.404202024-07-15T06:32:23Z http://eprints.um.edu.my/40420/ Zerumbone-loaded nanostructured lipid carrier gel enhances wound healing in diabetic rats Albaayit, Shaymaa Fadhel Abbas Abdullah, Rasedee Noor, Mohd Hezmee Mohd QR Microbiology S Agriculture (General) This study investigated the healing effects of topical application of zerumbone, a well-known anti-inflammatory compounds loaded on nanostructured lipid carrier gel (Carbopol 940) (ZER-NLCG) on excisional wounds in streptozotocin-induced diabetic rats. Diabetic rats with inflicted superficial skin wound were topically treated with ZER-NLCG, empty NLCG, and silver sulfadiazine cream (SSDC) once daily for 21 days. Wound tissue samples were analyzed for proinflammatory cytokines, namely, interleukin-6 (IL-6), interleukin-1 ss (IL-1 ss), and tumor necrosis factor-alpha (TNF-alpha), hydroxyproline contents, catalase, superoxide dismutase activities, and lipid peroxidation level, and were subjected to histopathological analysis, respectively. Among the treated groups, ZER-NLCG was the most effective at decreasing proinflammatory cytokine level and inflammatory cell infiltration while increasing antioxidant enzyme activities, hydroxyproline content, and granulation of wound tissues of diabetic rats. ZER-NLCG is a potent formulation for the enhancement of wound healing in diabetic rats through its antiinflammatory, antioxidant, and tissue repair activities. Hindawi Publishing Corporation 2022-09-10 Article PeerReviewed Albaayit, Shaymaa Fadhel Abbas and Abdullah, Rasedee and Noor, Mohd Hezmee Mohd (2022) Zerumbone-loaded nanostructured lipid carrier gel enhances wound healing in diabetic rats. BioMed Research International, 2022. ISSN 2314-6133, DOI https://doi.org/10.1155/2022/1129297 <https://doi.org/10.1155/2022/1129297>. https://doi.org/10.1155/2022/1129297 10.1155/2022/1129297 |
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QR Microbiology S Agriculture (General) Albaayit, Shaymaa Fadhel Abbas Abdullah, Rasedee Noor, Mohd Hezmee Mohd Zerumbone-loaded nanostructured lipid carrier gel enhances wound healing in diabetic rats |
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This study investigated the healing effects of topical application of zerumbone, a well-known anti-inflammatory compounds loaded on nanostructured lipid carrier gel (Carbopol 940) (ZER-NLCG) on excisional wounds in streptozotocin-induced diabetic rats. Diabetic rats with inflicted superficial skin wound were topically treated with ZER-NLCG, empty NLCG, and silver sulfadiazine cream (SSDC) once daily for 21 days. Wound tissue samples were analyzed for proinflammatory cytokines, namely, interleukin-6 (IL-6), interleukin-1 ss (IL-1 ss), and tumor necrosis factor-alpha (TNF-alpha), hydroxyproline contents, catalase, superoxide dismutase activities, and lipid peroxidation level, and were subjected to histopathological analysis, respectively. Among the treated groups, ZER-NLCG was the most effective at decreasing proinflammatory cytokine level and inflammatory cell infiltration while increasing antioxidant enzyme activities, hydroxyproline content, and granulation of wound tissues of diabetic rats. ZER-NLCG is a potent formulation for the enhancement of wound healing in diabetic rats through its antiinflammatory, antioxidant, and tissue repair activities. |
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Article |
author |
Albaayit, Shaymaa Fadhel Abbas Abdullah, Rasedee Noor, Mohd Hezmee Mohd |
author_facet |
Albaayit, Shaymaa Fadhel Abbas Abdullah, Rasedee Noor, Mohd Hezmee Mohd |
author_sort |
Albaayit, Shaymaa Fadhel Abbas |
title |
Zerumbone-loaded nanostructured lipid carrier gel enhances wound healing in diabetic rats |
title_short |
Zerumbone-loaded nanostructured lipid carrier gel enhances wound healing in diabetic rats |
title_full |
Zerumbone-loaded nanostructured lipid carrier gel enhances wound healing in diabetic rats |
title_fullStr |
Zerumbone-loaded nanostructured lipid carrier gel enhances wound healing in diabetic rats |
title_full_unstemmed |
Zerumbone-loaded nanostructured lipid carrier gel enhances wound healing in diabetic rats |
title_sort |
zerumbone-loaded nanostructured lipid carrier gel enhances wound healing in diabetic rats |
publisher |
Hindawi Publishing Corporation |
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2022 |
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http://eprints.um.edu.my/40420/ https://doi.org/10.1155/2022/1129297 |
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13.19449 |