Zerumbone-loaded nanostructured lipid carrier gel enhances wound healing in diabetic rats

• Main Authors: Albaayit, Shaymaa Fadhel Abbas, Abdullah, Rasedee, Noor, Mohd Hezmee Mohd
• Format: Article
• Published: Hindawi Publishing Corporation 2022
• Subjects: QR Microbiology; S Agriculture (General)
• Online Access: http://eprints.um.edu.my/40420/; https://doi.org/10.1155/2022/1129297

This study investigated the healing effects of topical application of zerumbone, a well-known anti-inflammatory compounds loaded on nanostructured lipid carrier gel (Carbopol 940) (ZER-NLCG) on excisional wounds in streptozotocin-induced diabetic rats. Diabetic rats with inflicted superficial skin wound were topically treated with ZER-NLCG, empty NLCG, and silver sulfadiazine cream (SSDC) once daily for 21 days. Wound tissue samples were analyzed for proinflammatory cytokines, namely, interleukin-6 (IL-6), interleukin-1 ss (IL-1 ss), and tumor necrosis factor-alpha (TNF-alpha), hydroxyproline contents, catalase, superoxide dismutase activities, and lipid peroxidation level, and were subjected to histopathological analysis, respectively. Among the treated groups, ZER-NLCG was the most effective at decreasing proinflammatory cytokine level and inflammatory cell infiltration while increasing antioxidant enzyme activities, hydroxyproline content, and granulation of wound tissues of diabetic rats. ZER-NLCG is a potent formulation for the enhancement of wound healing in diabetic rats through its antiinflammatory, antioxidant, and tissue repair activities.