Evaluation of the acute oral toxicity and antipsychotic activity of a dual inhibitor of PDE1B and PDE10A in rat model of schizophrenia

• Main Authors: Al-Nema, Mayasah, Gaurav, Anand, Lee, Ming Tatt, Okechukwu, Patrick, Nimmanpipug, Piyarat, Lee, Vannajan Sanghiran
• Format: Article
• Published: Public Library of Science 2022
• Subjects: R Medicine (General); RM Therapeutics. Pharmacology
• Online Access: http://eprints.um.edu.my/40266/

Phosphodiesterase 1B (PDE1B) and PDE10A are dual-specificity PDEs that hydrolyse both cyclic adenosine monophosphate and cyclic guanosine monophosphate, and are highly expressed in the striatum. Several reports have suggested that PDE10A inhibitors may present a promising approach for the treatment...