Evaluation of the acute oral toxicity and antipsychotic activity of a dual inhibitor of PDE1B and PDE10A in rat model of schizophrenia
Phosphodiesterase 1B (PDE1B) and PDE10A are dual-specificity PDEs that hydrolyse both cyclic adenosine monophosphate and cyclic guanosine monophosphate, and are highly expressed in the striatum. Several reports have suggested that PDE10A inhibitors may present a promising approach for the treatment...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Published: |
Public Library of Science
2022
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/40266/ |
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