Dinuclear and mononuclear metal(II) polypyridyl complexes against drug-sensitive and drug-resistant Plasmodium falciparum and their mode of action

• Main Authors: Lai, Jing Wei, Maah, Mohd Jamil, Tan, Kong Wai, Sarip, Rozie, Lim, Yvonne Ai Lian, Ganguly, Rakesh, Khaw, Loke Tim, Ng, Chew Hee
• Format: Article
• Published: BioMed Central 2022
• Subjects: RM Therapeutics. Pharmacology
• Online Access: http://eprints.um.edu.my/40240/

Background Malaria remains one of the most virulent and deadliest parasitic disease in the world, particularly in Africa and Southeast Asia. Widespread occurrence of artemisinin-resistant Plasmodium falciparum strains from the Greater Mekong Subregion is alarming. This hinders the national economies...