The clinical utility of CD163 in viral diseases

Macrophage activation and hypercytokinemia are notable presentations in certain viral infections leading to severe disease and poor prognosis. Viral infections can cause macrophage polarization into the pro-inflammatory M1 or anti-inflammatory M2 phenotype. Activated M1 macrophages usually restrict...

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Main Authors: Yap, Yi-Jing, Wong, Pooi Fong, AbuBakar, Sazaly, Sam, Sing Sin, Shunmugarajoo, Anusha, Soh, Yih-Harng, Misbah, Suzana, Rahman, Ahmad Kashfi Ab
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Published: Elsevier 2023
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Online Access:http://eprints.um.edu.my/38638/
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spelling my.um.eprints.386382024-11-04T05:03:02Z http://eprints.um.edu.my/38638/ The clinical utility of CD163 in viral diseases Yap, Yi-Jing Wong, Pooi Fong AbuBakar, Sazaly Sam, Sing Sin Shunmugarajoo, Anusha Soh, Yih-Harng Misbah, Suzana Rahman, Ahmad Kashfi Ab R Medicine RS Pharmacy and materia medica Macrophage activation and hypercytokinemia are notable presentations in certain viral infections leading to severe disease and poor prognosis. Viral infections can cause macrophage polarization into the pro-inflammatory M1 or anti-inflammatory M2 phenotype. Activated M1 macrophages usually restrict viral replication whereas activated M2 macrophages suppress inflammation and promote tissue repair. In response to inflammatory stimuli, macrophages polarize to the M2 phenotype expressing hemoglobin scavenger CD163 surface receptor. The CD163 receptor is shed as the soluble form, sCD163, into plasma or tissue fluids. sCD163 causes detoxification of pro-oxidative hemoglobin which produces anti-inflammatory metabolites that promote the resolution of inflammation. Hence, increased CD163 expression in tissues and elevated circulatory levels of sCD163 have been associated with acute and chronic inflammatory diseases. CD163 and other macrophage activation markers have been commonly included in the investigation of disease pathogenesis and progression. This review provides an overview of the involvement of CD163 in viral diseases. The clinical utility of CD163 in viral disease diagnosis, progression, prognosis and treatment evaluation is discussed. Elsevier 2023-02 Article PeerReviewed Yap, Yi-Jing and Wong, Pooi Fong and AbuBakar, Sazaly and Sam, Sing Sin and Shunmugarajoo, Anusha and Soh, Yih-Harng and Misbah, Suzana and Rahman, Ahmad Kashfi Ab (2023) The clinical utility of CD163 in viral diseases. Clinica Chimica Acta, 541. ISSN 0009-8981, DOI https://doi.org/10.1016/j.cca.2023.117243 <https://doi.org/10.1016/j.cca.2023.117243>. 10.1016/j.cca.2023.117243
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
RS Pharmacy and materia medica
spellingShingle R Medicine
RS Pharmacy and materia medica
Yap, Yi-Jing
Wong, Pooi Fong
AbuBakar, Sazaly
Sam, Sing Sin
Shunmugarajoo, Anusha
Soh, Yih-Harng
Misbah, Suzana
Rahman, Ahmad Kashfi Ab
The clinical utility of CD163 in viral diseases
description Macrophage activation and hypercytokinemia are notable presentations in certain viral infections leading to severe disease and poor prognosis. Viral infections can cause macrophage polarization into the pro-inflammatory M1 or anti-inflammatory M2 phenotype. Activated M1 macrophages usually restrict viral replication whereas activated M2 macrophages suppress inflammation and promote tissue repair. In response to inflammatory stimuli, macrophages polarize to the M2 phenotype expressing hemoglobin scavenger CD163 surface receptor. The CD163 receptor is shed as the soluble form, sCD163, into plasma or tissue fluids. sCD163 causes detoxification of pro-oxidative hemoglobin which produces anti-inflammatory metabolites that promote the resolution of inflammation. Hence, increased CD163 expression in tissues and elevated circulatory levels of sCD163 have been associated with acute and chronic inflammatory diseases. CD163 and other macrophage activation markers have been commonly included in the investigation of disease pathogenesis and progression. This review provides an overview of the involvement of CD163 in viral diseases. The clinical utility of CD163 in viral disease diagnosis, progression, prognosis and treatment evaluation is discussed.
format Article
author Yap, Yi-Jing
Wong, Pooi Fong
AbuBakar, Sazaly
Sam, Sing Sin
Shunmugarajoo, Anusha
Soh, Yih-Harng
Misbah, Suzana
Rahman, Ahmad Kashfi Ab
author_facet Yap, Yi-Jing
Wong, Pooi Fong
AbuBakar, Sazaly
Sam, Sing Sin
Shunmugarajoo, Anusha
Soh, Yih-Harng
Misbah, Suzana
Rahman, Ahmad Kashfi Ab
author_sort Yap, Yi-Jing
title The clinical utility of CD163 in viral diseases
title_short The clinical utility of CD163 in viral diseases
title_full The clinical utility of CD163 in viral diseases
title_fullStr The clinical utility of CD163 in viral diseases
title_full_unstemmed The clinical utility of CD163 in viral diseases
title_sort clinical utility of cd163 in viral diseases
publisher Elsevier
publishDate 2023
url http://eprints.um.edu.my/38638/
_version_ 1814933267531431936
score 13.211869