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Identification of Burkholderia pseudomallei Mimotope using Phage display approach

This study reportsa sequential biopanning against serum obtained from a patient infected with B. pseudomallei using a phage display peptide library. A peptide bearing the consensus sequence NKNSFDAWLQSF was obtained after 3 rounds of biopanning and it partly resembles the sequence 35FDAWLAAQEF44 of...

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Main Authors: Chua, K.H., Chai, H.C., Puthucheary, S.D.
Format: Article
Language:English
Published: 2008
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/3822/1/Identification_of_Burkholderia_pseudomallei_Mimotope_using_Phage_Display_Approach..pdf
http://eprints.um.edu.my/3822/
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spelling my.um.eprints.38222012-11-01T04:22:28Z http://eprints.um.edu.my/3822/ Identification of Burkholderia pseudomallei Mimotope using Phage display approach Chua, K.H. Chai, H.C. Puthucheary, S.D. R Medicine This study reportsa sequential biopanning against serum obtained from a patient infected with B. pseudomallei using a phage display peptide library. A peptide bearing the consensus sequence NKNSFDAWLQSF was obtained after 3 rounds of biopanning and it partly resembles the sequence 35FDAWLAAQEF44 of B. pseudomallei site-specific recombinase, which is a phage integrase family protein. Overall, the mimotope obtained in this study could be a potential candidate for the development of a cost effective diagnostic test or vaccine in the future. 2008 Article PeerReviewed application/pdf en http://eprints.um.edu.my/3822/1/Identification_of_Burkholderia_pseudomallei_Mimotope_using_Phage_Display_Approach..pdf Chua, K.H. and Chai, H.C. and Puthucheary, S.D. (2008) Identification of Burkholderia pseudomallei Mimotope using Phage display approach. Journal of Applied Sciences, 8 (21). pp. 3999-4003. ISSN 1812-5654
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic R Medicine
spellingShingle R Medicine
Chua, K.H.
Chai, H.C.
Puthucheary, S.D.
Identification of Burkholderia pseudomallei Mimotope using Phage display approach
description This study reportsa sequential biopanning against serum obtained from a patient infected with B. pseudomallei using a phage display peptide library. A peptide bearing the consensus sequence NKNSFDAWLQSF was obtained after 3 rounds of biopanning and it partly resembles the sequence 35FDAWLAAQEF44 of B. pseudomallei site-specific recombinase, which is a phage integrase family protein. Overall, the mimotope obtained in this study could be a potential candidate for the development of a cost effective diagnostic test or vaccine in the future.
format Article
author Chua, K.H.
Chai, H.C.
Puthucheary, S.D.
author_facet Chua, K.H.
Chai, H.C.
Puthucheary, S.D.
author_sort Chua, K.H.
title Identification of Burkholderia pseudomallei Mimotope using Phage display approach
title_short Identification of Burkholderia pseudomallei Mimotope using Phage display approach
title_full Identification of Burkholderia pseudomallei Mimotope using Phage display approach
title_fullStr Identification of Burkholderia pseudomallei Mimotope using Phage display approach
title_full_unstemmed Identification of Burkholderia pseudomallei Mimotope using Phage display approach
title_sort identification of burkholderia pseudomallei mimotope using phage display approach
publishDate 2008
url http://eprints.um.edu.my/3822/1/Identification_of_Burkholderia_pseudomallei_Mimotope_using_Phage_Display_Approach..pdf
http://eprints.um.edu.my/3822/
_version_ 1643687206244581376
score 13.214268

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