Identification of Burkholderia pseudomallei Mimotope using Phage display approach
This study reportsa sequential biopanning against serum obtained from a patient infected with B. pseudomallei using a phage display peptide library. A peptide bearing the consensus sequence NKNSFDAWLQSF was obtained after 3 rounds of biopanning and it partly resembles the sequence 35FDAWLAAQEF44 of...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
2008
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/3822/1/Identification_of_Burkholderia_pseudomallei_Mimotope_using_Phage_Display_Approach..pdf http://eprints.um.edu.my/3822/ |
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| Summary: | This study reportsa sequential biopanning against serum obtained from a patient infected with B. pseudomallei using a phage display peptide library. A peptide bearing the consensus sequence NKNSFDAWLQSF was obtained after 3 rounds of biopanning and it partly resembles the sequence 35FDAWLAAQEF44 of B. pseudomallei site-specific recombinase, which is a phage integrase family protein. Overall, the mimotope obtained in this study could be a potential candidate for the development of a cost effective diagnostic test or vaccine in the future. |
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