A Cyclodextrin-Stabilized Spermine-Tagged Drug Triplex that Targets Theophylline to the Lungs Selectively in Respiratory Emergency

• Main Authors: Sofian, Zarif M., Benaouda, Faiza, Wang, Julie Tzu-Wen, Lu, Yuan, Barlow, David J., Royall, Paul G., Farag, Doaa B., Rahman, Khondaker Miraz, Al-Jamal, Khuloud T., Forbes, Ben, Jones, Stuart A.
• Format: Article
• Published: WILEY 2020
• Online Access: http://eprints.um.edu.my/36394/

Ion-pairing a lifesaving drug such as theophylline with a targeting moiety could have a significant impact on medical emergencies such as status asthmaticus or COVID-19 induced pneumomediastinum. However, to achieve rapid drug targeting in vivo the ion-pair must be protected against breakdown before...