Intracellular and exosomal microRNAome profiling of human vascular smooth muscle cells during replicative senescence

• Main Authors: Nguyen, Diem Duong Ngoc, Zain, Shamsul Mohd, Kamarulzaman, Mohd Hamzah, Low, Teck Yew, Chilian, William M., Pan, Yan, Ting, Kang Nee, Hamid, Aini, Kadir, Arifah Abdul, Pung, Yuh-Fen
• Format: Article
• Published: Amer Physiological Soc 2021
• Subjects: R Medicine; RC Internal medicine
• Online Access: http://eprints.um.edu.my/35342/

Vascular aging is highly associated with cardiovascular morbidity and mortality. Although the senescence of vascular smooth muscle cells (VSMCs) has been well established as a major contributor to vascular aging, intracellular and exosomal microRNA (miRNA) signaling pathways in senescent VSMCs have...