The return of chloroquine-sensitive Plasmodium falciparum parasites in Jazan region, southwestern Saudi Arabia over a decade after the adoption of artemisinin-based combination therapy: Analysis of genetic mutations in the pfcrt gene

• Main Authors: Madkhali, Aymen M., Abdulhaq, Ahmed A., Atroosh, Wahib M., Ghzwani, Ahmad Hassn, Zain, Khalid Ammash, Ghailan, Khalid Y., Hamali, Hassan A., Mobarki, Abdullah A., Eisa, Zaki M., Lau, Yee-Ling, Al-Mekhlafi, Hesham M.
• Format: Article
• Published: Springer Verlag (Germany) 2021
• Subjects: QR Microbiology; R Medicine; RA Public aspects of medicine; RB Pathology
• Online Access: http://eprints.um.edu.my/34447/

This study investigated the polymorphism in the P. falciparum chloroquine resistance transporter (pfcrt) gene 11 years after chloroquine (CQ) cessation in Jazan region, southwestern Saudi Arabia. Two hundred and thirty-five P. falciparum isolates were amplified to detect mutations in the pfcrt gene....