Breast cancer in a multi-ethnic Asian setting: results from the Singapore-Malaysia hospital-based breast cancer registry

• Main Authors: Pathy, Nirmala Bhoo, Yip, Cheng Har, Mohd Taib, Nur Aishah, Hartman, Mikael, Saxena, Nakul, Iau, Philip, Bulgiba, Awang, Lee, Soo Chin, Lim, S.E., Wong, John E.L., Verkooijen, Helena M.
• Format: Article
• Language: English
• Published: Elsevier 2011
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/3058/1/Breast_cancer_in_a_multi-ethnic_Asian_setting_Results_from_the_Singapore-Malaysia.pdf; http://eprints.um.edu.my/3058/; https://doi.org/10.1016/j.breast.2011.01.015

Two hospital-based breast cancer databases (University Malaya Medical Center, Malaysia n = 1513 and National University Hospital, Singapore n = 2545) were merged into a regional registry of breast cancer patients diagnosed between 1990 and 2007. A review of the data found 51% of patients diagnosed before the age of 50 years. and 72% percent of the women were Chinese followed by Malays (16%), Indians (8%), and other races (4%). Median tumor size at presentation was 26 mm and about 25% of patients presented with TNM stage III or IV disease. Most tumors were of ductal histology (87%). Fifty-seven percent of tumors were estrogen receptor positive and 40% were poorly differentiated. Of those patients who had surgery, 70% had mastectomy while 30% had breast conserving surgery. Overall, chemotherapy was administered to 56% of patients and hormonal treatment to 60%. Five-year overall survival was 82.5% in patients with TNM stage 0 to stage II cancer, and 30.2% in those with later stages. (C) 2011 Elsevier Ltd. All rights reserved.