Rapid identification of cyclic Tetrapyrrolic Photosensitisers for Photodynamic therapy using on-line hyphenated LC-PDA-MS coupled with photo-cytotoxicity assay

• Main Authors: Tan, P.J., Appleton, D.R., Mustafa, Mohd Rais, Lee, H.B.
• Format: Article
• Language: English
• Published: 2011
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/3032/1/Rapid_Identification_of_Cyclic_Tetrapyrrolic.pdf; http://eprints.um.edu.my/3032/; http://onlinelibrary.wiley.com/doi/10.1002/pca.1324/full

Introduction � Photodynamic therapy is a treatment modality that involves site�directed generation of cytotoxic reactive oxygen species by light�activated photosensitisers. Objective � In order to rapidly identify new photosensitisers from natural extracts, we developed a liquid chromatograp...