Mutation analysis of SOD1, C9orf72, TARDBP and FUS genes in ethnically-diverse Malaysian patients with amyotrophic lateral sclerosis (ALS)

• Main Authors: Edgar, Suzanna, Ellis, Melina, Abdul-Aziz, Nur Adilah, Goh, Khean-Jin, Shahrizaila, Nortina, Kennerson, Marina L., Ahmad-Annuar, Azlina
• Format: Article
• Published: Elsevier 2021
• Subjects: HQ The family. Marriage. Woman; RC Internal medicine
• Online Access: http://eprints.um.edu.my/28666/

Recent studies have identified SOD1, FUS, TARDBP and C9orf72 as major ALS-related genes in both European and Asian populations. However, significant differences exist in the mutation frequencies of these genes between various ancestral backgrounds. This study aims to identify the frequency of mutati...