A review on plant flavonoids as potential anticancer agents

• Main Authors: Kapoor, Bhupinder, Gulati, Monica, Gupta, Reena, Singh, Sachin Kumar, Gupta, Mukta, Nabi, Arshid, Chawla, Pooja A.
• Format: Article
• Published: Bentham Science Publ Ltd 2021
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://eprints.um.edu.my/28645/

Flavonoids are polyphenolic compounds that are mainly derived from fruits and vegetables and constitute an essential part of plant-derived beverages such as green tea, wine and cocoa-based products. They have been shown to possess anticancer effects via different mechanisms such as carcinogen inactivation, antiproliferation, cell cycle arrest, induction of apoptosis and differentiation, inhibition of angiogenesis, anti-oxidation and reversal of multidrug resistance or a combination of any two or more of these mechanisms. The present review summarizes the chemistry, biosynthesis and anticancer evaluation of flavonoids in both animal and human studies. A special emphasis has been placed on the flavonoids that are being screened in different phases of clinical trials for chemopmtective action against various cancers.