Extracellular ATP Induced S-Phase Cell Cycle Arrest via P2Y Receptor-Activated ERK Signaling in Poorly Differentiated Oral Squamous Cell Carcinoma SAS Cells

• Main Authors: Lau, Chia Chih, Aminuddin, Amnani, Chan, Kok Meng, Paterson, Ian C., Law, Lok Mun, Ng, Pei Yuen
• Format: Article
• Published: MDPI
• Online Access: http://eprints.um.edu.my/28276/

Extracellular ATP in the tumor microenvironment exhibits either pro- or antitumor effect via interaction with P2Y receptors, but the intracellular signaling and functional roles of P2Y receptors in oral squamous cell carcinoma (OSCC) are unclear. We aimed to study the effect of ATP on OSCC cell line...