P2Y purinergic receptor signaling in oral squamous cell carcinoma cell lines and its role in proliferation and cisplatin-mediated apoptosis

• Main Authors: Lok, Mun Law, Norazrina Azmi,, Paterson, Ian Charles, Ng, Pei Yuen
• Format: Article
• Language: English
• Published: Penerbit Universiti Kebangsaan Malaysia 2022
• Online Access: http://journalarticle.ukm.my/18356/1/14.pdf; http://journalarticle.ukm.my/18356/; https://www.ukm.my/jsm/malay_journals/jilid51bil1_2022/KandunganJilid51Bil1_2022.html

Treatment of advanced stage oral squamous cell carcinoma (OSCC) often involves the use of chemotherapeutic agents, such as cisplatin. However, its use often results in therapeutic failure due to chemoresistance. This study focused on a class of purinergic receptors, namely P2Y, which are activated v...