Naproxen release aspect from boron-doped carbon nanodots as a bifunctional agent in cancer therapy
In this present study, boron-carbon nanodots were synthesized by the hydrothermal method. Boron-carbon nanodots were prepared by varying the concentration ratios of boronic acid and citric acid: 1 : 25, 2 : 1, and 25 : 1, respectively. The precursors were then poured into a Teflon autoclave and heat...
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my.um.eprints.280132022-07-08T03:34:43Z http://eprints.um.edu.my/28013/ Naproxen release aspect from boron-doped carbon nanodots as a bifunctional agent in cancer therapy Wibrianto, Aswandi Putri, Dinar F. Sakti, Satya C. W. Lee, Hwei Voon Fahmi, Mochamad Z. QD Chemistry In this present study, boron-carbon nanodots were synthesized by the hydrothermal method. Boron-carbon nanodots were prepared by varying the concentration ratios of boronic acid and citric acid: 1 : 25, 2 : 1, and 25 : 1, respectively. The precursors were then poured into a Teflon autoclave and heated at 240 degrees for 4 h. This research aims to synthesise and evaluate the potential of boron-carbon nanodots as a bioimaging agent and naproxen delivery carrier. An X-ray diffractogram showed that the boron-carbon nanodots were amorphous. To analyse the functional groups, FTIR and XPS analysis was carried out. Spectrofluorometric analysis (lambda(ex) 320 nm) showed that the formulation of boron-carbon nanodots 2 : 1 (BCD 2 : 1) has the most ideal fluorescent properties at lambda(em) 453 nm, whereas UV-vis analysis showed lambda(max) at 223 nm, with a quantum yield of 52.29%. A confocal laser scanning micrograph and toxicity test (MTT assays) showed that boron-carbon nanodots delivered naproxen efficiently with loading amount and loading efficiency of naproxen 28% and 65%, respectively. Furthermore, it induced an anticancer effect in HeLa cells. This result indicated that boron-carbon nanodots can be used as a bioimaging agent and naproxen delivery carrier. Royal Society of Chemistry 2021-11-22 Article PeerReviewed Wibrianto, Aswandi and Putri, Dinar F. and Sakti, Satya C. W. and Lee, Hwei Voon and Fahmi, Mochamad Z. (2021) Naproxen release aspect from boron-doped carbon nanodots as a bifunctional agent in cancer therapy. RSC Advances, 11 (59). pp. 37375-37382. ISSN 2046-2069, DOI https://doi.org/10.1039/d1ra06148h <https://doi.org/10.1039/d1ra06148h>. 10.1039/d1ra06148h |
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QD Chemistry Wibrianto, Aswandi Putri, Dinar F. Sakti, Satya C. W. Lee, Hwei Voon Fahmi, Mochamad Z. Naproxen release aspect from boron-doped carbon nanodots as a bifunctional agent in cancer therapy |
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In this present study, boron-carbon nanodots were synthesized by the hydrothermal method. Boron-carbon nanodots were prepared by varying the concentration ratios of boronic acid and citric acid: 1 : 25, 2 : 1, and 25 : 1, respectively. The precursors were then poured into a Teflon autoclave and heated at 240 degrees for 4 h. This research aims to synthesise and evaluate the potential of boron-carbon nanodots as a bioimaging agent and naproxen delivery carrier. An X-ray diffractogram showed that the boron-carbon nanodots were amorphous. To analyse the functional groups, FTIR and XPS analysis was carried out. Spectrofluorometric analysis (lambda(ex) 320 nm) showed that the formulation of boron-carbon nanodots 2 : 1 (BCD 2 : 1) has the most ideal fluorescent properties at lambda(em) 453 nm, whereas UV-vis analysis showed lambda(max) at 223 nm, with a quantum yield of 52.29%. A confocal laser scanning micrograph and toxicity test (MTT assays) showed that boron-carbon nanodots delivered naproxen efficiently with loading amount and loading efficiency of naproxen 28% and 65%, respectively. Furthermore, it induced an anticancer effect in HeLa cells. This result indicated that boron-carbon nanodots can be used as a bioimaging agent and naproxen delivery carrier. |
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Article |
author |
Wibrianto, Aswandi Putri, Dinar F. Sakti, Satya C. W. Lee, Hwei Voon Fahmi, Mochamad Z. |
author_facet |
Wibrianto, Aswandi Putri, Dinar F. Sakti, Satya C. W. Lee, Hwei Voon Fahmi, Mochamad Z. |
author_sort |
Wibrianto, Aswandi |
title |
Naproxen release aspect from boron-doped carbon nanodots as a bifunctional agent in cancer therapy |
title_short |
Naproxen release aspect from boron-doped carbon nanodots as a bifunctional agent in cancer therapy |
title_full |
Naproxen release aspect from boron-doped carbon nanodots as a bifunctional agent in cancer therapy |
title_fullStr |
Naproxen release aspect from boron-doped carbon nanodots as a bifunctional agent in cancer therapy |
title_full_unstemmed |
Naproxen release aspect from boron-doped carbon nanodots as a bifunctional agent in cancer therapy |
title_sort |
naproxen release aspect from boron-doped carbon nanodots as a bifunctional agent in cancer therapy |
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Royal Society of Chemistry |
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2021 |
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http://eprints.um.edu.my/28013/ |
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1738510687659884544 |
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13.18916 |