Investigating how amine structure influences drug-amine ion-pair formation and uptake via the polyamine transporter in A549 lung cells

• Main Authors: Mohamed Sofian, Zarif, Harun, Norsyifa, Mahat, Mohd Muzamir, Nor Hashim, Nikman Adli, Jones, Stuart A.
• Format: Article
• Published: Elsevier 2021
• Subjects: RM Therapeutics. Pharmacology; RS Pharmacy and materia medica
• Online Access: http://eprints.um.edu.my/27967/

Transiently associating amines with therapeutic agents through the formation of ion-pairs has been established both in vitro and in vivo as an effective means to systemically direct drug delivery to the lung via the polyamine transport system (PTS). However, there remains a need to better understand...