Homology modeling of the human 5-HT(1A), 5-HT (2A), D1, and D2 receptors: model refinement with molecular dynamics simulations and docking evaluation

• Main Authors: Yap, B.K., Buckle, M.J., Doughty, S.W.
• Format: Article
• Published: 2012
• Subjects: RS Pharmacy and materia medica
• Online Access: http://eprints.um.edu.my/2781/; http://www.ncbi.nlm.nih.gov/pubmed/22354276

5-HT(1A) serotonin and D1 dopamine receptor agonists have been postulated to be able to improve negative and cognitive impairment symptoms of schizophrenia, while partial agonists and antagonists of the D2 and 5-HT(2A) receptors have been reported to be effective in reducing positive symptoms. There...