Effect of antisense oligodeoxynucleotides for ICAM-1 on renal ischaemia–reperfusion injury in the anaesthetised rat

• Main Authors: Kiew, L.V., Abdul Sattar, M., Law, C.H., Abdullah, N.A., Abdul Rahman, N., Khalifah Sidik, K., Edward J. Johns, E.J.
• Format: Article
• Language: English
• Published: Cambridge University Press 2004
• Subjects: R Medicine (General); RB Pathology; RM Therapeutics. Pharmacology; RS Pharmacy and materia medica
• Online Access: http://eprints.um.edu.my/2641/1/Kiew_LV_2004.docx; http://eprints.um.edu.my/2641/

An antisense oligodeoxynucleotide (As-ODN) to the 3’ untranslated region of the mRNA sequence expressing the intracellular adhesion molecule-1 (ICAM-1) was employed to determine ICAM-1’s role in renal ischaemia–reperfusion injury in the rat. Wistar-Kyoto rats receiving I.V. either lipofectin–As-ODN...