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Singaporentine A: A New Indole Alkaloid from Kopsia singapurensis Ridl.

Study on chemical constituents from the leaves of Kopsia singapurensis (Apocynaceae) yielded a new indole alkaloid, singaporentine A (1) together with two known alkaloids, kopsifoline A (2) and kopsininic acid (3). The structure of 1 was elucidated by combination of various spectroscopic methods suc...

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Bibliographic Details
Main Authors: Awang, Khalijah, Ahmad, Kartini, Thomas, Noel Francis, Hirasawa, Yusuke, Takeya, Koichi, Mukhtar, Mat Ropi, Mohamad, Khalit, Morita, Hiroshi
Format: Article
Published: The Japan Institute of Heterocyclic Chemistry 2008
Subjects:
QD Chemistry
RS Pharmacy and materia medica
Online Access:http://eprints.um.edu.my/25494/
https://doi.org/10.3987/COM-08-11438
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Summary:Study on chemical constituents from the leaves of Kopsia singapurensis (Apocynaceae) yielded a new indole alkaloid, singaporentine A (1) together with two known alkaloids, kopsifoline A (2) and kopsininic acid (3). The structure of 1 was elucidated by combination of various spectroscopic methods such as MS, UV, IR, ID and 2D NMR. Singaporentine A exhibited cytotoxic activity against P388 murine leukemia cells. © 2008 The Japan Institute of Heterocyclic Chemistry.

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