Microwave synthesis of hydroxyapatite encumbered with ascorbic acid intended for drug leaching studies

• Main Authors: Padmanabhan, Varun Prasath, Kulandaivelu, Ravichandran, Santhana Panneer, Devendrapandi, Vivekananthan, S., Sagadevan, Suresh, Lett, J. Anita
• Format: Article
• Published: Taylor & Francis 2020
• Subjects: Q Science (General); QC Physics; QD Chemistry
• Online Access: http://eprints.um.edu.my/25436/; https://doi.org/10.1080/14328917.2019.1624940

The characteristics properties of hydroxyapatite (HAP, Ca10 (PO4)6(OH) 2) namely, bioactivity, biocompatibility, osteoconductive and adsorption capacity can be tailored over wide assortments by governing the particle composition, particle dimensions, and structure. Pure hydroxyapatite (HAP) nanoparticles were synthesized by a simple straightforward approach using microwave irradiation method. The prepared HAP samples were studied for phase purity using X-ray diffractometer (XRD); functional group analysis using Fourier transform Infrared (FTIR) spectroscopy. Scanning electron microscopy (SEM) and Transmission electron microscopy (TEM) was used to examine the assembling of the HAP particles. These outcomes validate that shorter rod–like HAP particles can be organized by microwave irradiation technique. The synthesized HAP samples were loaded with ascorbic acid to analyze it’s in vitro drug release studies and its biocompatibility was confirmed by means of MTT assay using Saos-2 cell lines (Human Osteosarcoma Cell Line). © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.