Severe dengue categories as research endpoints—Results from a prospective observational study in hospitalised dengue patients

• Main Authors: Horstick, Olaf, Rosenberger, Kerstin D., Alexander, Neal, Martinez, Eric, Lum, Lucy Chai See, Dempfle, Carl-Erik, Junghanss, Thomas, Wills, Bridget, Jaenisch, Thomas
• Format: Article
• Published: Public Library of Science 2020
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/25244/; https://doi.org/10.1371/journal.pntd.0008076

Severe dengue was perceived as one clinical disease entity until the WHO 2009 classification stratified it into severe vascular leakage, severe bleeding, and severe organ dysfunc-tion. The objectives of this study were to investigate the potential use of severe dengue categories as endpoints for int...