Geranylated 4-phenylcoumarins extracted from Mesua elegans induced caspase-independent cell death in prostate cancer cell lines through calpain-2 and cathepsin B

• Main Authors: Sapili, Hani, Ho, Chai San, Malagobadan, Sharan, Arshad, Norhafiza Mohd, Nagoor, Noor Hasima
• Format: Article
• Published: Nature Research 2020
• Subjects: Q Science (General); QH Natural history
• Online Access: http://eprints.um.edu.my/25129/; https://doi.org/10.1038/s41598-020-57781-6

Geranylated 4-phenylcoumarins DMDP-1 and DMDP-2 isolated from Mesua elegans were elucidated for their role in inducing caspase-independent programmed cell death (CI-PCD) in prostate cancer cell lines, PC-3 and DU 145, respectively. Cell homeostasis disruption was demonstrated upon treatment, as show...