Geranylated 4-phenylcoumarins extracted from Mesua elegans induced caspase-independent cell death in prostate cancer cell lines through calpain-2 and cathepsin B
Geranylated 4-phenylcoumarins DMDP-1 and DMDP-2 isolated from Mesua elegans were elucidated for their role in inducing caspase-independent programmed cell death (CI-PCD) in prostate cancer cell lines, PC-3 and DU 145, respectively. Cell homeostasis disruption was demonstrated upon treatment, as show...
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| Main Authors: | , , , , |
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| Format: | Article |
| Published: |
Nature Research
2020
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/25129/ https://doi.org/10.1038/s41598-020-57781-6 |
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