The development of a novel transforming growth factor-β (TGF-β) inhibitor that disrupts ligand-receptor interactions

• Main Authors: Wu, Han, Sun, Yu, Wong, Wee Lin, Cui, Jiajia, Li, Jingyang, You, Xuefu, Yap, Lee Fah, Huang, Yu, Hong, Wei, Yang, Xinyi, Paterson, Ian Charles, Wang, Hao
• Format: Article
• Published: Elsevier 2020
• Subjects: R Medicine; TP Chemical technology
• Online Access: http://eprints.um.edu.my/24750/; https://doi.org/10.1016/j.ejmech.2020.112042

Transforming growth factor-β (TGF-β) plays an important role in regulating epithelial to mesenchymal transition (EMT) and the TGF-β signaling pathway is a potential target for therapeutic intervention in the development of many diseases, such as fibrosis and cancer. Most currently available inhibito...