Development of small molecule inhibitors targeting TGF-β ligand and receptor: Structures, mechanism, preclinical studies and clinical usage

• Main Authors: Wang, Hao, Chen, Meiling, Sang, Xiaohong, You, Xuefu, Wang, Yucheng, Paterson, Ian Charles, Hong, Wei, Yang, Xinyi
• Format: Article
• Published: Elsevier 2020
• Subjects: R Medicine; TP Chemical technology
• Online Access: http://eprints.um.edu.my/24767/; https://doi.org/10.1016/j.ejmech.2020.112154

Transforming growth factor-β (TGF-β) is a member of a superfamily of pleiotropic proteins that regulate multiple cellular processes such as growth, development and differentiation. Following binding to type I and II TGF-β serine/threonine kinase receptors, TGF-β activates downstream signaling cascad...