Oncogenic Signaling in Tumorigenesis and Applications of siRNA Nanotherapeutics in Breast Cancer
Overexpression of oncogenes and cross-talks of the oncoproteins-regulated signaling cascades with other intracellular pathways in breast cancer could lead to massive abnormal signaling with the consequence of tumorigenesis. The ability to identify the genes having vital roles in cancer development w...
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my.um.eprints.241752020-04-08T05:53:00Z http://eprints.um.edu.my/24175/ Oncogenic Signaling in Tumorigenesis and Applications of siRNA Nanotherapeutics in Breast Cancer Kamaruzman, Nur Izyani Aziz, Noraini Abd Poh, Chit Laa Chowdhury, Ezharul Hoque R Medicine Overexpression of oncogenes and cross-talks of the oncoproteins-regulated signaling cascades with other intracellular pathways in breast cancer could lead to massive abnormal signaling with the consequence of tumorigenesis. The ability to identify the genes having vital roles in cancer development would give a promising therapeutics strategy in combating the disease. Genetic manipulations through siRNAs targeting the complementary sequence of the oncogenic mRNA in breast cancer is one of the promising approaches that can be harnessed to develop more efficient treatments for breast cancer. In this review, we highlighted the effects of major signaling pathways stimulated by oncogene products on breast tumorigenesis and discussed the potential therapeutic strategies for targeted delivery of siRNAs with nanoparticles in suppressing the stimulated signaling pathways. © 2019, MDPI AG. All rights reserved. MDPI 2019 Article PeerReviewed Kamaruzman, Nur Izyani and Aziz, Noraini Abd and Poh, Chit Laa and Chowdhury, Ezharul Hoque (2019) Oncogenic Signaling in Tumorigenesis and Applications of siRNA Nanotherapeutics in Breast Cancer. Cancers, 11 (5). p. 632. ISSN 2072-6694 https://doi.org/10.3390/cancers11050632 doi:10.3390/cancers11050632 |
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R Medicine Kamaruzman, Nur Izyani Aziz, Noraini Abd Poh, Chit Laa Chowdhury, Ezharul Hoque Oncogenic Signaling in Tumorigenesis and Applications of siRNA Nanotherapeutics in Breast Cancer |
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Overexpression of oncogenes and cross-talks of the oncoproteins-regulated signaling cascades with other intracellular pathways in breast cancer could lead to massive abnormal signaling with the consequence of tumorigenesis. The ability to identify the genes having vital roles in cancer development would give a promising therapeutics strategy in combating the disease. Genetic manipulations through siRNAs targeting the complementary sequence of the oncogenic mRNA in breast cancer is one of the promising approaches that can be harnessed to develop more efficient treatments for breast cancer. In this review, we highlighted the effects of major signaling pathways stimulated by oncogene products on breast tumorigenesis and discussed the potential therapeutic strategies for targeted delivery of siRNAs with nanoparticles in suppressing the stimulated signaling pathways. © 2019, MDPI AG. All rights reserved. |
format |
Article |
author |
Kamaruzman, Nur Izyani Aziz, Noraini Abd Poh, Chit Laa Chowdhury, Ezharul Hoque |
author_facet |
Kamaruzman, Nur Izyani Aziz, Noraini Abd Poh, Chit Laa Chowdhury, Ezharul Hoque |
author_sort |
Kamaruzman, Nur Izyani |
title |
Oncogenic Signaling in Tumorigenesis and Applications of siRNA Nanotherapeutics in Breast Cancer |
title_short |
Oncogenic Signaling in Tumorigenesis and Applications of siRNA Nanotherapeutics in Breast Cancer |
title_full |
Oncogenic Signaling in Tumorigenesis and Applications of siRNA Nanotherapeutics in Breast Cancer |
title_fullStr |
Oncogenic Signaling in Tumorigenesis and Applications of siRNA Nanotherapeutics in Breast Cancer |
title_full_unstemmed |
Oncogenic Signaling in Tumorigenesis and Applications of siRNA Nanotherapeutics in Breast Cancer |
title_sort |
oncogenic signaling in tumorigenesis and applications of sirna nanotherapeutics in breast cancer |
publisher |
MDPI |
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2019 |
url |
http://eprints.um.edu.my/24175/ https://doi.org/10.3390/cancers11050632 |
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1665895217129062400 |
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13.209306 |