siRNA blocking of mammalian target of rapamycin (mTOR) attenuates pathology in annonacin-induced tauopathy in mice

• Main Authors: Salama, Mohamed M., El-Desouky, Sara, Alsayed, Aziza, El-Hussiny, Mahmoud, Magdy, Khaled, Fekry, Emad, Shabka, Osama, El-Khodery, Sabry A., Youssef, Mohamed A., Sobh, Mohamed, Mohamed, Wael Mohamed Yousef
• Format: Article
• Language: English; English; English
• Published: Springer Nature Switzerland AG 2019
• Subjects: R Medicine (General); RM300 Drugs and their action
• Online Access: http://irep.iium.edu.my/67119/1/mTOR.pdf; http://irep.iium.edu.my/67119/7/67119_siRNA%20Blocking%20of%20Mammalian%20Target%20of%20Rapamycin%20%28mTOR%29%20Attenuates%20Pathology%20in%20Annonacin-Induced%20Tauopathy%20in%20Mice_wos.pdf; http://irep.iium.edu.my/67119/13/67119_siRNA%20Blocking%20of%20Mammalian%20Target%20of%20Rapamycin%20mTOR_scopus.pdf; http://irep.iium.edu.my/67119/; https://link.springer.com/article/10.1007/s12640-018-9974-3

Tauopathy is a pathological hallmark of many neurodegenerative diseases. It is characterized by abnormal aggregates of pathological phosphotau and somatodendritic redistribution. One suggested strategy for treating tauopathy is to stimulate autophagy, hence, getting rid of these pathological protein...